Our approach
How do we create
a more reliable
colorectal connection?
Our starting point is a simple question: can more precise tissue contact create better conditions for healing and prevent leakage?
The answer begins where the tissues meet.
01 / Why the submucosa matters
01The healing
interface.
The submucosa is a collagen-rich connective-tissue layer that contributes importantly to the mechanical strength of the intestinal wall. It contains collagen, elastin and fibroblasts involved in repair.
Implican is designed to bring the submucosal layers of the two bowel ends into precise, direct apposition.
02 / How Implican connects
Direct tissue contact
without staple rows
crossing the interface.
Unlike staple-mediated approximation, the Implican principle does not rely on rows of staples crossing the healing interface. The device establishes a defined compression interface that brings the submucosal layers together.
The design objective is simple: create a precise starting point for tissue repair while minimising unnecessary disruption at the interface.
03 / The biology
Designed for primary
wound healing.
Primary wound healing depends on accurate tissue apposition. Intestinal repair then progresses through a coordinated sequence of inflammation, fibroblast activity, collagen deposition and remodelling, angiogenesis and re-epithelialization.
Implican is engineered to give these biological processes a defined starting point.
See the instrument details and preclinical histology04 / Preclinical outcome
04Evidence before
clinical development.
The current Implican preclinical programme includes a porcine series in which no anastomotic leaks were observed. Histological assessment provides additional evidence on the character and progression of the healing response.
These findings support further development. They are not evidence of clinical performance in people.
05 / Clinical development
Progressed to initial
in-human use.
Implican has progressed to initial in-human use. Thereafter, the programme will perform a prospective leakage impact study and a further prospective clinical evaluation for stoma reduction, including safety establishment, technical performance, healing and leakage.
Prevention of leakage and reduction of stoma formation are clinical development objectives that require prospective clinical validation.
Scientific detail